The SARS-CoV-2 S1 Total Abs test is a serological immunoassay that detects antibodies against the spike protein S1 subunit of the SARS-CoV-2 virus, the causative agent of COVID-19 infection. This test assesses humoral immune response monitoring in response to viral exposure. It is indicated in confirming acute and past infections, assessing vaccine effectiveness, and identifying potential immunity, prevalence, and viral spread in the community.