The Reflex antibody test detects the presence of antibodies against adalimumab, a human therapeutic monoclonal antibody used in treating various autoimmune diseases, including rheumatoid arthritis, ankylosing spondylitis, and psoriasis. The presence of neutralizing antibodies hampers the treatment efficacy of adalimumab. This test helps to assess drug effectiveness loss, assisting clinicians to optimize therapeutic drug dosage and adopt alternative therapies for better outcomes.