Fondaparinux is an oral anticoagulant inhibiting factor Xa, a critical protein in the blood coagulation cascade that causes the conversion of prothrombin to thrombin. Anti-Xa assays are used to monitor the levels of drugs like fondaparinux. This assay is used to monitor anticoagulant therapy, ensure therapeutic levels, and minimize bleeding risks in cases of deep vein thrombosis, pulmonary embolism, or other clotting disorders.

References:

• Turpie AG. Fondaparinux: a Factor Xa inhibitor for antithrombotic therapy. Expert Opin Pharmacother. 2004 June;5(6):1373-84. doi: 10.1517/14656566.5.6.1373. Accessed on Jan 31st,2024.
• Turpie AG, Eriksson BI, Lassen MR, Bauer KA. Fondaparinux, the first selective factor Xa inhibitor. Curr Opin Hematol. 2003 September;10(5):327-32. doi: 10.1097/00062752-200309000-00001.Accessed on Jan 31st,2024.
• Data on File: PureLab DOS V5, November 10^th, 2023.