Paroxysmal Nocturnal Hemoglobinuria (PNH) is a rare acquired hematopoietic stem cell disorder. This testing procedure allows a high sensitivity detection of GPI deficient cells by Flowcytometry on WBC (both granulocytes and monocytes) and RBC cells for diagnosis and monitoring treatment response.

The hemolytic form of the disease is characterized by complement-dependent lysis of RBCs and it is caused by a defective expression of cell surface proteins. The use of FLAER labeling on leukocytes proves that this reagent is a valuable tool for PNH diagnosis and particularly appropriate for high-sensitivity tests aiming to detect minor PNH clones.