Human Leukocyte Antigen (HLA) Class I molecules are crucial in immune mechanisms and can show associations with drug hypersensitivity reactions. Low-intermediate resolution HLA typing helps to identify alleles related to drug sensitivity and disease associations. Analyzing low- or intermediate-resolution HLA provides valuable insights about susceptibility to adverse drug reactions such as Stevens-Johnson syndrome or toxic epidermal necrolysis, optimizing drug selection (allopurinol, abacavir, carbamazepine), and minimizing risks.