Human Leukocyte Antigen (HLA) Class II low-intermediate resolution typing involves identifying human leukocyte antigen system allele groups, mainly HLA-DRB1 and HLA-DQB1 genes, to provide insight about predisposing medical diseases. This typing shows association with autoimmune diseases, including rheumatoid arthritis, type 1 diabetes, Crohn’s, rheumatic heart disease, and celiac disease. Identifying genetic predispositions to medical conditions helps develop targeted, personalized treatment approaches.