The Oligoclonal Bands (OCBs) in the cerebrospinal fluid (CSF) test identifies the central humoral response. CSF-restricted OCBs are indicative of multiple sclerosis (MS) its presence is also observed in other central nervous system disorders and neurodegenerative conditions. Healthcare professionals utilize this test to identify conditions such as systemic infections, autoimmune diseases, sarcoidosis, MS, or neoplasia.