TCR gamma Gene Clonality is a molecular genetic study used to assess the clonality of T-cell receptor gamma (TCRγ) genes involved in the pathogenesis of lymphomas and leukaemias. The pattern of polyclonal bands indicates a diverse population of T-cells, typical in reactive processes, and the monoclonal pattern suggests malignancy. This study helps diagnose, plan therapy, evaluate prognosis and monitor treatment response.