Encephalopathy autoimmune evaluation serum involves a set of serum tests to derive valuable information about the presence of cytokines, autoantibodies against NMDA receptor, voltage-gated potassium channel, GAD, anti-Ma2, anti-LGI1 antibodies, CRP and metabolic indicators of immune activity in the central nervous system. Encephalopathy is a group of brain disorders with altered mental function or consciousness. Analysis helps in the evaluation and management of autoimmune encephalopathy.