Anti-TIF-1gamma antibodies, called anti-p155 antibodies, are specific autoantibodies associated with dermatomyositis, interfering with cellular functions. Dermatomyositis is an autoimmune inflammatory condition affecting muscles and skin, presenting with symmetric proximal muscle weakness and signature cutaneous findings. Detecting anti-TIF-1gamma antibodies in a patient’s serum helps diagnose and classify dermatomyositis, providing insights about treatment decisions, prognosis, and monitoring disease progression.