Xylenes are a group of isomeric chemicals such as meta-xylene, para-xylene, and ortho-xylene. They are volatile organic compounds (VOCs) commonly found in industrial products, paints, varnishes, adhesives, and solvents. Its exposure can occur through inhalation, ingestion, or skin contact, leading to health hazards. The concentration of xylene metabolites indicates recent exposure to xylenes. It helps follow appropriate occupational safety practices and minimize exposure.