Parvovirus B19 is a viral infection involved in several clinical syndromes, including erythema infectiosum (fifth disease) and aplastic crisis in individuals with hemolytic disorders. IgG and IgM antibody testing help to determine the individual’s immune status; IgG antibodies suggest past infection, and IgM antibodies suggest acute recent infection. These tests are necessary for accurate diagnosis and management of Parvovirus B19 infections.