The direct antiglobulin test (DAT), or Coombs test, looks for immunoglobulin and/or complement on the surface of red blood cells. The potential diagnosis of the Coombs test comprises pre-transfusion testing, hemolytic transfusion reactions, and autoimmune or drug-induced hemolytic anaemias. DAT Polyassays aid healthcare providers in diagnosing drug-induced immune hemolytic anemia (DIHA). and consequently, in the proper selection of therapeutic modalities.