HLA Class II typing at low-intermediate resolution involves detecting Class II broad human leukocyte antigen system, HLA-DRB1, and HLA-DQB1 gene alleles using lower-intermediate resolution immunogenic systems. These antigens are primarily found on the surface of antigen-presenting cells (APCs) and B cells. This testing is helpful in preliminary assessments of organ transplantation compatibility, disease screenings, polymorphism, and genetic diversity.