PM Scl Antibodies are immunological assays aiming to detect antibodies directed against the PMSCL protein, commonly found in the cell nucleus, a common association in autoimmune diseases. These antibodies are associated with a rare autoimmune disease known as polymyositis-scleroderma overlap syndrome or systemic sclerosis (scleroderma). This test helps in evaluating patients with clinical suspicion of soft tissue disorders, assisting in diagnosis.