Gout and pseudogout are the two most prevalent crystalline abnormality of joints are caused by deposition of monosodium urate (MSU) and calcium pyrophosphate dihydrate (CPPD) crystals, respectively. Such deposition causes inflammation, pain, and destruction of the joint. Identifying MSU and calcium CPPD crystals aids healthcare professionals in rapid and definitive diagnosis of both gout and CPPD arthritis.