Von Willebrand Factor (vWF) is a glycoprotein that mediates adhesion of platelets to the site of vascular injury, protecting Factor VIII from degradation in the bloodstream and promoting platelet aggregation. Measuring vWF antigen levels is indicated to diagnose bleeding disorder and von Willebrand disease. Abnormal vWF levels can lead to bleeding tendencies. Testing helps in the accurate diagnosis and therapeutic management of bleeding disorders.
References:
- Favaloro EJ, Mohammed S, Patzke J. Laboratory Testing for von Willebrand Factor Antigen (VWF:Ag). Methods Mol Biol. 2017;1646:403-416. doi: 10.1007/978-1-4939-7196-1_30. Accessed on Jan 31st,2024.
- Sukhu K, Martin PG, Cross L, Keeling DM, Giangrande PL. Evaluation of the von Willebrand factor antigen (vWF-Ag) assay using an immuno-turbidimetric method (STA Liatest vWF) automated on the MDA 180 coagulometer. Clin Lab Haematol. 2000 February;22(1):29-32. doi: 10.1046/j.1365-2257.2000.00281.x.Accessed on Jan 31st,2024.
- Data on File: PureLab DOS V5, November 10th, 2023.
