CD4 count for immune monitoring (including T and NK cells, without B cells)
Clusters of Differentiation 4 (CD4) count is an important immune marker for monitoring Human Immunodeficiency Viruses (HIV) infection and immune disorders. CD4 counting and monitoring NK cell activity help to assess cell-mediated immunity, cytotoxic function, and cytokine production. Immune assessment provides a comprehensive picture of immune health to monitor, prognosticate, and manage immune disorders.
Leukocyte Adhesion Molecules
This assay helps in the diagnosis of Leukocyte adhesion deficiency (LAD). LAD is a rare disease which can be further classified into LAD Type I and LAD Type II. In LAD, phagocytes are unable to adhere to the endothelium or migrate to tissues in response to an infection. This study is indicated in inflammatory, and […]
PNH by Flow
Paroxysmal Nocturnal Hemoglobinuria (PNH) is a rare acquired hematopoietic stem cell disorder. This testing procedure allows a high sensitivity detection of GPI deficient cells by Flowcytometry on WBC (both granulocytes and monocytes) and RBC cells for diagnosis and monitoring treatment response. The hemolytic form of the disease is characterized by complement-dependent lysis of RBCs and […]
Platelet Receptors Flow
This test is used for the diagnosis of Glanzmann’s Thrombasthenia and Bernard-Soulier Syndrome. Platelet flowcytometric analysis is the preferred method to assess hereditary platelet disorders due to surface glycoprotein (GP) deficiencies. Glanzmann’s Thrombasthenia (GT) is characterized by the absence or reduced expression of platelet glycoprotein (GP) IIb/IIIa. GPIIb/IIIa is analyzed on the flow cytometer using […]
Lymphocyte Subset Panel (including T, B and NK cells)
A Lymphocyte Subset Panel is a diagnostic test that quantifies and assesses the distribution of lymphocyte subsets in blood, specifically T cells, B cells, and natural killer (NK) cells. These lymphocyte subsets are crucial immune cells in cell-mediated, humoral, and innate immunity. These cells are assessed by fluorescent-labeled surface marker antibodies such as CD3, CD4, […]
CD4/CD8 by flow (BAL)
Measuring the ratio of CD4 to CD8 T-cell lymphocyte subsets in bronchoalveolar lavage fluid is an important diagnostic tool. It helps differentiate the etiology of interstitial lung disease in scenarios where there is a clinical dilemma. Immunophenotyped CD4 and CD8 cells are measured through flow cytometry. A higher CD4/CD8 level indicates sarcoidosis.
