HLA-B27
HLA-B27 is a type of class I major histocompatibility complex (MHC) molecule found on the surface of all nucleated cells. Typing for histocompatibility antigen, HLA-B27 has been suggested as a helpful diagnostic test for ankylosing spondylitis (AS), reactive arthritis, juvenile rheumatoid arthritis (JRA), or sometimes anterior uveitis.
Virtual crossmatch for Deceased donation
Deceased donor organ transplantation virtual crossmatch is compatibility testing between the deceased donor and potential recipient. It is performed prior to without physically performing crossmatch tests. It utilizes data about the recipient’s and donor’s human leukocyte antigen typing and antibody profiles, predicting compatibility. Tests help guide the decision-making process about organ allocation and transplantation during […]
Chimerism Post Transplant (T cells)
Chimerism post-transplantation, concerning T cells, evaluates the presence of donor-derived T lymphocytes in the recipient’s body after hematopoietic stem cell or cellular infusions. Monitoring helps determine the extent of T cell engraftment in the recipient’s body as high chimerism indicates successful engraftment and reconstitution of the T cell immune system. Monitoring is crucial for assessing […]
Chimerism-Recipient Germline (Pre-Transplant)
Chimerism analysis is used to assess the unique features of donor and recipient DNA before a hematopoietic stem cell transplant (HSCT). This analysis is particularly relevant in the context of allogeneic transplantation, where cells from a donor are used to replace the recipient’s hematopoietic system for the purpose of engraftment. Important note: This sample mandatory […]
Chimerism-Donor
Chimerism evaluates the presence of two genetically distinct cell populations in an individual resulting from transplantation procedures. Depending on the engraftment requirement, the degree of donor chimerism is essential, which can vary from low chimerism with a small percentage of cells of donor origin to complete or full chimerism with a majority of donor cells. […]
Chimerism Transplant (Post) without cell selection
Chimerism can be defined as the presence of two genetically different cell populations in a person resulting from transplantation procedures. In post-transplant settings, chimerism analysis helps to monitor the degree of engraftment of donor tissue cells in the recipient’s body. It is performed with molecular assays PCR, FISH or short tandem repeat analysis. Monitoring indicates […]
Chimerism-Donor
Post HSCT transplant chimerism testing examines the effectiveness of allogeneic hematopoietic stem cell transplantation by monitoring the engraftment proportion of viable donor cells compared to remaining recipient cells in the patient. The Chimerism-Donor test is used to assess a HSCT donor’s genotype and compare it to a recipient’s genotype. It is performed prior to allogenic […]
IgE Allergy, Acacia Tree
Pollen from the Acacia tree is known to act as an allergen commonly exposed through the inhalation of airborne pollen during the flowering season. It leads to a type I hypersensitivity reaction manifested with respiratory symptoms such as sneezing, coughing, wheezing, and bronchial asthma. Healthcare professionals utilize this test to assess sensitivity and provide guidance […]
HLA Class II Typing (Low-Intermediate Resolution)
HLA Class II typing at low-intermediate resolution involves detecting Class II broad human leukocyte antigen system, HLA-DRB1, and HLA-DQB1 gene alleles using lower-intermediate resolution immunogenic systems. These antigens are primarily found on the surface of antigen-presenting cells (APCs) and B cells. This testing is helpful in preliminary assessments of organ transplantation compatibility, disease screenings, polymorphism, […]
HLA Class I Typing (Low-Intermediate Resolution)
HLA Class I typing at low-intermediate resolution involves identifying broad human leukocyte antigen system allele groups on HLA-A, B, and C genes using lower- or intermediate-resolution immunogenic systems. This testing is commonly employed in preliminary assessments of compatibility in organ transplantation, disease screenings, and community genomic studies to provide an HLA Class I genetic profile.
