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HLA Class II Disease Association (Low-Intermediate Resolution)

Human Leukocyte Antigen (HLA) Class II low-intermediate resolution typing involves identifying human leukocyte antigen system allele groups, mainly HLA-DRB1 and HLA-DQB1 genes, to provide insight about predisposing medical diseases. This typing shows association with autoimmune diseases, including rheumatoid arthritis, type 1 diabetes, Crohn’s, rheumatic heart disease, and celiac disease. Identifying genetic predispositions to medical conditions […]

HLA Class I Drug Hypersensitivity and Disease Association (Low-Intermediate Resolution)

Human Leukocyte Antigen (HLA) Class I molecules are crucial in immune mechanisms and can show associations with drug hypersensitivity reactions. Low-intermediate resolution HLA typing helps to identify alleles related to drug sensitivity and disease associations. Analyzing low- or intermediate-resolution HLA provides valuable insights about susceptibility to adverse drug reactions such as Stevens-Johnson syndrome or toxic […]

HLA B51

HLA-B51 refers to a specific human leukocyte antigen allele present in the HLA-B locus. The significance of this genomic region is that it codes for proteins involved in the immune system. The HLA-B51 association shows a higher prevalence with some autoimmune diseases, mainly Behçet’s disease, presenting with recurrent genital ulcers, skin lesions, and uveitis. HLA […]

HLA Class I and II Typing for Solid Organ Donor (Low-Intermediate Resolution)

HLA Class I and II typing for solid organ donors at low-intermediate resolution identifies general allele groups, with sequence-specific primer PCR or sequence-specific oligonucleotide probing, for assessing types of HLA-A, B, C (Class I), and HLA-DRB1, DQB1 (Class II) genes with lower resolution broader categorization.  It helps with donor-recipient matching for solid organ transplantation, and […]

HLA Class I and II Typing for HSCT Donor (Low-Intermediate Resolution)

HLA Class I and II typing for hematopoietic stem cell transplant (HSCT) donors at low-intermediate resolution involves identifying broader allele groups with techniques of sequence-specific primer PCR or sequence-specific oligonucleotide probing with intermediate resolution. This method assesses HLA-A, -B, and -C (Class I) and HLA-DRB1 and DQB1 (Class II) genes. Matching helps to identify compatible […]

HLA Class I and II Typing (High resolution)

High-resolution HLA Class I and II typing is carried out with advanced genotyping techniques that identify specific alleles for HLA molecules. This study provides a highly precise and detailed analysis distinguishing structural variations in HLA-A, -B, -C (Class I), and HLA-DRB1, -DRB3/4/5, -DQA1, -DQB1, DPA1, -DPB1 (Class II) genes. High-resolution typing enhances compatibility assessments.   […]

HLA Flow T and B cell Crossmatch

Human Leukocyte Antigen (HLA) Flow T and B Cell Crossmatching in Organ Transplantation involves evaluating recipient IgG antibodies against donor T and B lymphocytes with the help of flow cytometry assays, a highly precise pre-transplantation immunological workup adopted in solid organ transplantation. This study identifies antibodies indicating potential rejection risk, assessing the extent of donor-recipient […]

Serum storage (6 months)

Serum storage for six months involves preserving blood serum samples under controlled conditions while maintaining sample integrity and safety. Serum is stored at -20°C or lower in labeled aliquots under regulated and monitored temperature conditions that inhibit enzymatic and biochemical degradation, alterations in protein stability, and degradation of labile analytes. Monitoring temperature and quality checks, […]

HLA Antibody Screen Class I and Class II

This is an important pre-transplant immunological study indicated in the organ transplantation process. This study evaluates immune reactions against human leukocyte antigens (HLA) by screening antibodies against Class I (HLA-A, -B, -C) and Class II (HLA-DR, -DP, -DQ) in the recipient’s body using solid base platforms, or Luminex bead assays. A positive result indicates pre-existing […]

HLA Antibody Identification Class I

HLA antibody identification in Class I involves the detection of human leukocyte antigen (HLA) class I antigen molecules present on the surface of cells. The test targets identifying antibodies against HLA-A, -B, and -C antigens on solid-based platforms, or Luminex bead assays. This is an essential immunological workup for organ transplantation compatibility assessment to prevent […]